Welcome to the Biotrib Research Publications Database. This collection comprises of research articles, reviews, and other scholarly works originating from the BioTrib consortium.
Every publication listed here has undergone meticulous scientific scrutiny and contributes to the broader understanding of joint mechanics, material behavior, and the complex interplay between biology and tribology.
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Clegg, Ben A; Shrestha, Dilesh Raj; Emami, Nazanin Tribo-Mechanical Properties and Bioactivity of Additively Manufactured PAEK Materials for Load Bearing Medical Applications: A Systematic Review Journal Article In: Biotribology, pp. 100263, 2023. Abstract | Links | BibTeX | Tags: Plath, Andre M Souza; Huber, Stephanie; Alfarano, Serena R; Abbott, Daniel F; Hu, Minghan; Mougel, Victor; Isa, Lucio; Ferguson, Stephen J Co-Electrospun Poly (ε-Caprolactone)/Zein Articular Cartilage Scaffolds Journal Article In: Bioengineering, vol. 10, no. 7, pp. 771, 2023. Abstract | Links | BibTeX | Tags: 2023
@article{clegg2023tribo,
title = {Tribo-Mechanical Properties and Bioactivity of Additively Manufactured PAEK Materials for Load Bearing Medical Applications: A Systematic Review},
author = {Clegg, Ben A and Shrestha, Dilesh Raj and Emami, Nazanin},
url = {https://www.sciencedirect.com/science/article/pii/S2352573823000306},
year = {2023},
date = {2023-12-01},
journal = {Biotribology},
pages = {100263},
abstract = {Additive manufacturing (AM) holds significant potential in transforming medical applications, with a particular focus on polyetheretherketone (PEEK) and its derivatives, collectively known as poly-aryl-ether-ketone (PAEK) materials. Advances in AM precision have paved the way for the successful 3D printing of high-performance thermoplastics like PEEK, offering new prospects in load-bearing medical applications. This systematic review comprehensively assesses recent scientific literature concerning the tribo-mechanical properties and bioactivity of additively manufactured PAEK materials, with a specific emphasis on PEEK, for load-bearing medical uses. Despite substantial research into AM of metallic biomaterials, knowledge gaps persist regarding AM processing parameters, structure-property relationships, biological behaviours, and implantation suitability of PAEKs. This review bridges these gaps by analysing existing literature on the tribo-mechanical properties and bioactivity of additively manufactured PAEK materials, providing valuable insights into their performance in load-bearing medical applications. Key aspects explored include printing conditions, strength limitations, and outcomes of in-vitro and in-vivo evaluations. Through this systematic review, we consolidate current knowledge, delivering essential information for researchers, clinicians, and manufacturers involved in advancing additively manufactured PAEK materials for load-bearing medical applications.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{plath2023co,
title = {Co-Electrospun Poly (ε-Caprolactone)/Zein Articular Cartilage Scaffolds},
author = {Andre M Souza Plath and Stephanie Huber and Serena R Alfarano and Daniel F Abbott and Minghan Hu and Victor Mougel and Lucio Isa and Stephen J Ferguson},
url = {https://www.mdpi.com/2306-5354/10/7/771},
doi = {10.3390/bioengineering10070771},
year = {2023},
date = {2023-01-01},
urldate = {2023-01-01},
journal = {Bioengineering},
volume = {10},
number = {7},
pages = {771},
publisher = {MDPI},
abstract = {Osteoarthritis scaffold-based grafts fail because of poor integration with the surrounding soft tissue and inadequate tribological properties. To circumvent this, we propose electrospun poly(ε-caprolactone)/zein-based scaffolds owing to their biomimetic capabilities. The scaffold surfaces were characterized using Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, static water contact angles, and profilometry. Scaffold biocompatibility properties were assessed by measuring protein adsorption (Bicinchoninic Acid Assay), cell spreading (stained F-actin), and metabolic activity (PrestoBlue™ Cell Viability Reagent) of primary bovine chondrocytes. The data show that zein surface segregation in the membranes not only completely changed the hydrophobic behavior of the materials, but also increased the cell yield and metabolic activity on the scaffolds. The surface segregation is verified by the infrared peak at 1658 cm−1, along with the presence and increase in N1 content in the survey XPS. This observation could explain the decrease in the water contact angles from 125° to approximately 60° in zein-comprised materials and the decrease in the protein adsorption of both bovine serum albumin and synovial fluid by half. Surface nano roughness in the PCL/zein samples additionally benefited the radial spreading of bovine chondrocytes. This study showed that co-electrospun PCL/zein scaffolds have promising surface and biocompatibility properties for use in articular-tissue-engineering applications.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}